Binghui Shen, Ph.D.
Professor and Chair, Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope
Research Area
- Okazaki Fragment Maturation in DNA Replication
- DNA Repair and Genome Stability
- Cancer Genetics
Academic Appointments
- Professor, Irell & Manella Graduate School of Biological Sciences
- Co-leader, Molecular Oncology Program, Comprehensive Cancer Center
- Co-director, NCI-funded T32 Program
- 2018 American Association for the Advancement of Science Fellow
Research Teams
Molecular and Cellular Biology
Our laboratory focuses on understanding the cellular mechanisms that maintain and disrupt genomic stability, contributing to many diseases, particularly cancer. The genome is especially vulnerable during DNA replication. Our lab studies the mechanisms underlying DNA replication and DNA damage response and repair in normal and cancer cells using multidisciplinary techniques, including biochemical, cellular, structural biological, and chemical approaches and genetic mouse modeling.