John S. Kaddis, Ph.D.
Associate Professor, Department of Diabetes & Cancer Discovery Science
Research Area
- Diabetes
- Systems Biology
- Biostatistics
- Bioinformatics
Academic Appointments
Associate Professor, Department of Diabetes & Cancer Discovery Science
John Kaddis, Ph.D, is an associate professor in the Department of Diabetes & Cancer Discovery Science within the Arthur Riggs Diabetes & Metabolism Research Institute at City of Hope®.
For 15 years at City of Hope, Dr. Kaddis has delved into the complex mechanisms of type 1 diabetes, devising scientific resources for team-based research initiatives. The data systems, analysis tools and websites created for collaboration have been used by researchers all over the world. Dr. Kaddis currently serves as a principal investigator and co-investigator on several projects funded by the National Institutes of Health and the JDRF.
Dr. Kaddis has relished laboratory inquiry and analysis for a very long time. While earning his biochemistry degree from California State University Los Angeles, he completed undergraduate research supported by two National Science Foundation fellowships. He earned his doctorate in systems biology and disease from the University of Southern California.
A competitor in more than a dozen marathons and triathlons, Dr. Kaddis is an equally athletic communicator with over 60 publications and presentations to his credit. Dr. Kaddis invests the stamina and perseverance of a long distance runner to the painstaking research of type 1 diabetes, diving deep into pools of data to amass critical information which may one day lead to a cure.
Education & Experience
Degrees
- 2011, Ph.D., Systems Biology and Disease, University of Southern California, Los Angeles, CA
- 2001, B.S. (Honors), Biochemistry, California State University Los Angeles, Los Angeles, CA
Fellowship
- 2000–2001, Undergraduate Fellowship, National Science Foundation Collaborative Research in Undergraduate Institutions
- 1999, Undergraduate Fellowship, National Science Foundation Center for Environmental Analysis-Center for Research Excellence in Science and Technology
Professional Experience
- 2022–present, Associate Professor, Department of Diabetes & Cancer Discovery Science, Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope, Duarte, CA
- 2017–Present, Assistant Professor, Department of Diabetes & Cancer Discovery Science, Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope, Duarte, CA
- 2015–2017, Assistant Professor, Department of Research Information Sciences, Beckman Research Institute of City of Hope, Duarte, CA
- 2006–2011, Graduate Research Assistant, University of Southern California, Los Angeles, CA
- 2005–2015, Project Administrator, National Islet Cell Resource Center Program, Beckman Research Institute of City of Hope, Duarte, CA
- 2002–2005, Consortium Manager, National Islet Cell Resource Center Program, Beckman Research Institute of City of Hope, Duarte, CA
- 2001–2002, Validation Scientist, Validation Department, International Medication Systems, El Monte, CA
- 2000–2002, Clinical Research Assistant, Department of Cardiology, Long Beach Veterans Administration, Long Beach, CA Hospital
- 2000–2001, Laboratory Research Assistant, Department of Chemistry and Biochemistry, California State University Los Angeles, Los Angeles, CA
Research
Kaddis Lab
09/15/2014-06/30/2019
U01 DK104147 Kaddis (PI)
NIDDK
Human Islet Research Network Bioinformatics Center
While the availability of biomedical “big data” presents a remarkable opportunity for innovation and translational advances in type 1 diabetes research, the deluge of information has created significant challenges in the scientific community. The establishment of a centralized bioinformatics center to address these barriers facilitates the ultimate goal of understanding the causes of type 1 diabetes and developing therapies capable of curing the disorder.
Role: Contact Principal Investigator
01/01/2013-12/31/2017
Subcontracts #UF 13026, UPDSP00010084 Kaddis (PI)
University of Florida
JDRF Grant #25-2013-268
JDRF nPOD DataShare
Integration of data is central to the overall mission and success of the Network for Pancreatic Organ Donors with Diabetes Data Management Core (nPOD-DMC). The specific aim is to devise a means to improve collaboration and increase research productivity through the implementation of a web-based resource. The objective is to provide nPOD staff and investigators with the ability to organize, analyze, and share data over the internet collaboratively using a mature and secure data sharing platform customized and branded to the needs of nPOD.
Role: Sub-award Principal Investigator
09/15/2014-06/30/2019
U01 DK104162 Niland (PI)
NIDDK
Human Islet Research Network Coordinating Center
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is funding the Human Islet Research Network (HIRN), with the overall goal of developing innovative strategies for the treatment, prevention and cure of type I diabetes. This new undertaking will establish a network of consortia through which innovative scientists will conduct translational research related to loss of functional beta cell mass in type 1 diabetes. HIRN investigators will be supported by a coordinating center (HIRN-CC) and Bioinformatics Center (HIRN-BC), serving together as the HIRN Administrative Hub.
Role: Co-investigator
9/30/2009 – 8/30/2019
U01 DK085532 Niland (PI)
NIH/NIDDK
Intestinal Stem Cell Coordinating Center
Diseases affecting the small intestine represent a diverse collection of conditions that can cause anything from diarrhea to death in affected individuals. Understanding the biology of the small intestine will aid in the development of therapies to treat intestinal diseases. This proposal established and maintains the Intestinal Stem Cell Consortium (ISCC) Coordinating Center (CC). The CC supports the ISCC in establishing establish efficient and effective procedures for the preservation, isolation, and characterization of intestinal stem cells, while developing and validating specific markers for this population of cells. The CC works with investigators from five to sevent different research projects to optimize study administration, coordination, quality control and information management.
Role: Co-investigator
U01 DK104147 Kaddis (PI)
NIDDK
Human Islet Research Network Bioinformatics Center
While the availability of biomedical “big data” presents a remarkable opportunity for innovation and translational advances in type 1 diabetes research, the deluge of information has created significant challenges in the scientific community. The establishment of a centralized bioinformatics center to address these barriers facilitates the ultimate goal of understanding the causes of type 1 diabetes and developing therapies capable of curing the disorder.
Role: Contact Principal Investigator
01/01/2013-12/31/2017
Subcontracts #UF 13026, UPDSP00010084 Kaddis (PI)
University of Florida
JDRF Grant #25-2013-268
JDRF nPOD DataShare
Integration of data is central to the overall mission and success of the Network for Pancreatic Organ Donors with Diabetes Data Management Core (nPOD-DMC). The specific aim is to devise a means to improve collaboration and increase research productivity through the implementation of a web-based resource. The objective is to provide nPOD staff and investigators with the ability to organize, analyze, and share data over the internet collaboratively using a mature and secure data sharing platform customized and branded to the needs of nPOD.
Role: Sub-award Principal Investigator
09/15/2014-06/30/2019
U01 DK104162 Niland (PI)
NIDDK
Human Islet Research Network Coordinating Center
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is funding the Human Islet Research Network (HIRN), with the overall goal of developing innovative strategies for the treatment, prevention and cure of type I diabetes. This new undertaking will establish a network of consortia through which innovative scientists will conduct translational research related to loss of functional beta cell mass in type 1 diabetes. HIRN investigators will be supported by a coordinating center (HIRN-CC) and Bioinformatics Center (HIRN-BC), serving together as the HIRN Administrative Hub.
Role: Co-investigator
9/30/2009 – 8/30/2019
U01 DK085532 Niland (PI)
NIH/NIDDK
Intestinal Stem Cell Coordinating Center
Diseases affecting the small intestine represent a diverse collection of conditions that can cause anything from diarrhea to death in affected individuals. Understanding the biology of the small intestine will aid in the development of therapies to treat intestinal diseases. This proposal established and maintains the Intestinal Stem Cell Consortium (ISCC) Coordinating Center (CC). The CC supports the ISCC in establishing establish efficient and effective procedures for the preservation, isolation, and characterization of intestinal stem cells, while developing and validating specific markers for this population of cells. The CC works with investigators from five to sevent different research projects to optimize study administration, coordination, quality control and information management.
Role: Co-investigator
Awards & Memberships
Memberships
- 2011–Present, Member, American Association for the Advancement of Science)
- 2010–Present, Professional Member, American Diabetes Association
- 2003–2012, Member, Society of Clinical Research Associates
- 2000–Present, Lifetime Member, Tri-Beta Honor Society
Publications
- Hospital time prior to death and pancreas histopathology: implications for future studies. Kusmartseva I, Beery M, Philips T, Selman S, Jadhav P, Wasserfall C, Muller A, Pugliese A, Longmate JA, Schatz DA, Atkinson MA, Kaddis JS. Diabetologia. 2018 Apr;61(4):954-958
- Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity. Yan KS, Gevaert O, Zheng GXY, Anchang B, Probert CS, Larkin KA, Davies PS, Cheng ZF, Kaddis JS, Han A, Roelf K, Calderon RI, Cynn E, Hu X, Mandleywala K, Wilhelmy J, Grimes SM, Corney DC, Boutet SC, Terry JM, Belgrader P, Ziraldo SB, Mikkelsen TS, Wang F, von Furstenberg RJ, Smith NR, Chandrakesan P, May R, Chrissy MAS, Jain R, Cartwright CA, Niland JC, Hong YK, Carrington J, Breault DT, Epstein J, Houchen CW, Lynch JP, Martin MG, Plevritis SK, Curtis C, Ji HP, Li L, Henning SJ, Wong MH, Kuo CJ. Cell Stem Cell. 2017 Jul 6;21(1):78-90.e6.
- Factors That Influence the Quality of RNA From the Pancreas of Organ Donors. Philips T, Kusmartseva I, Gerling IC, Campbell-Thompson M, Wasserfall C, Pugliese A, Longmate JA, Schatz DA, Atkinson MA, Kaddis JS. Pancreas. 2017 Feb;46(2):252-259.
- Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes. Seay HR, Yusko E, Rothweiler SJ, Zhang L, Posgai AL, Campbell-Thompson M, Vignali M, Emerson RO, Kaddis JS, Ko D, Nakayama M, Smith MJ, Cambier JC, Pugliese A, Atkinson MA, Robins HS, Brusko TM. JCI Insight. 2016 Dec 8;1(20):e88242.
- Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes. Richardson SJ, Rodriguez-Calvo T, Gerling IC, Mathews CE, Kaddis JS, Russell MA, Zeissler M, Leete P, Krogvold L, Dahl-Jørgensen K, von Herrath M, Pugliese A, Atkinson MA, Morgan NG. Diabetologia. 2016 Nov;59(11):2448-2458.
- For updates, see our publication list at PubMed.
Key Publications
- In a 2009 special issue of Journal of American Medical Association dedicated to diabetes, we published a key article highlighting research with human islet cells — its importance, its limitations and its potential for better treating or preventing the disease. The same paper was selected for presentation at the National Press Club in Washington, DC.
- In a second publication in JAMA, this time a research letter in 2012, we focused on the human pancreas. Our study documented the extent to which type 1 diabetes seems to degrade the organ, which weighs less in people with type 1 diabetes and in those with biomarkers that precede the disease’s manifestation compared to individuals in the control group.