Xiwei Wu, Ph.D.
Professor, Department of Computational and Quantitative Medicine
Xiwei Wu, Ph.D., is an Professor in the Department of Computational and Quantitative Medicine within Beckman Research Institute of City of Hope.
Education & Experience
2002, Ph.D., Loma Linda University, Microbiology & Molecular Genetics, mentor: Dr. Carlos A. Casiano, Chancellor’s award
1997, M.D., Tianjin Medical University
2004, Postdoctoral Fellow, University of California, San Diego, Rheumatic Disease Center, Mentor: Dr. Gregg Silverman
2002-2004, Postdoctoral Fellow, Keck Graduate Institute, Henry E. Riggs School of Applied Life Sciences, Mentor: Dr. T. Gregory Dewey
- 2013 - Present, Director, Integrative Genomics Core, City of Hope
- 2013 - Present, Research Professor, Dept. Molecular and Cellular Biology, City of Hope
- 2011 - 2013, Associate Research Professor, Dept. Molecular and Cellular Biology, City of Hope
- 2004 - 2011, Assistant Research Professor, Dept. Biomedical Informatics, City of Hope
- 2009 - 2013, Associate Director, Bioinformatics Core
Research
Lab Members
V. Active Grants/Research Support
- 08/01/2012 – 11/30/2022 P30CA033572 (Rosen, S) NIH/NCI, Integrative Genomics and Bioinformatics Core Annual Direct Support: $103,523, Role: Core Director
Pending Grants/Research Support
05/01/2022 -04/30/2024, Pending (Chen, W) CIRM, Sex-based targeting of myeloid leukemia stem cells Annual Direct Support: $900,000
Completed Grants/Research Support
09/22/2006 – 07/31/2011, R01ES015185 (Szabo, P), NIH/ NIEHS, Epigenetic Effects of Endocrine Disruptors in Fetal Germ Annual Direct Support: $238,336, Role: Co-investigator
08/10/2007 – 06/30/2010, R21CA128495 (Pfeifer, G), NIH/NCI, DNA Methylation in Cancer Genomes, Annual Direct Support: $126,497, Role: Co-investigator
12/01/2007 – 11/30/2012, P30CA033572-26 (Figlin, R) NIH/NCI, Cancer Center Support Grant, Annual Direct Support: $1,402,679, Role: Core Director
05/01/2009 – 02/28/2014, R01CA084469 (Pfeifer, G), NIH/NCI, CpG methylation and mutation, Annual Direct Support: $175,000, Role: Co-investigator
07/01/2009 – 06/30/2011, R21CA137570 (Li, Z), NIH/NCI, Profiling autoantibodies for early detection of esophageal squamous cell carcinoma Annual Direct Support: $108,846, Role: Co-investigator
08/01/2009 – 04/30/2014, R37ES006070 (Pfeifer, G), NIH/NIESH, UV damage, repair, and mutagenesis, Annual Direct Support: $250,000, Role: Co-investigator
12/01/2017 – 11/30/2019, R21CA223367 (Hanh, M), NIH/NCI, Epigenomic Biomarkers to Manage Thyroid Nodule Overdiagnosis and Overtreatment, Annual Direct Support: $113,368, Role: Co-investigator
Awards & Memberships
Awards
1999, Selma Andrews Award, Loma Linda University
Memberships
American Society of Cell Biology
Publications
- Lee IS, Zhu Z, Lee J, Park JO, Wu X, Ong T, Li SM, Wang X, Chao J, Goel A. A liquid biopsy signature predicts treatment response to fluoropyrimidine plus platinum therapy in patients with metastatic or unresectable gastric cancer: implications for precision oncology. Mol Cancer. 2022 Jan 3;21(1):9.
- Mori H, Saeki K, Chang G, Wang J, Wu X, Hsu PY, Kanaya N, Wang X, Somlo G, Nakamura M, Bild A, Chen S. Influence of Estrogen Treatment on ESR1+ and ESR1- Cells in ER+ Breast Cancer: Insights from Single-Cell Analysis of Patient-Derived Xenograft Models. Cancers (Basel). 2021 Dec 19;13(24):6375.
- Sun H, Lu Z, Singh A, Zhou Y, Zheng E, Zhou M, Wang J, Wu X, Hu Z, Gu Z, Campbell JL, Zheng L, Shen B. Error- prone, stress-induced 3' flap-based Okazaki fragment maturation supports cell survival. Science. 2021 Dec3;374(6572):1252-1258.
- Chaurasiya S, Yang A, Zhang Z, Lu J, Valencia H, Kim SI, Woo Y, Warner SG, Olafsen T, Zhao Y, Wu X, Fein S, Cheng L, Cheng M, Ede N, Fong Y. A comprehensive preclinical study supporting clinical trial of oncolytic chimeric poxvirus CF33-hNIS-anti-PD-L1 to treat breast cancer. Mol Ther Methods Clin Dev. 2021 Dec 6;24:102-116.
- Abdulla FR, Zhang W, Wu X, Honda K, Qin H, Cho H, Querfeld C, Zain J, Rosen ST, Chan WC, Parekh V, Song JY. Genomic Analysis of Cutaneous CD30-Positive Lymphoproliferative Disorders. JID Innov. 2021 Nov 15;2(1):100068.
- Di Raimondo C, Han Z, Su C, Wu X, Qin H, Sanchez JF, Yuan YC, Martinez X, Abdulla F, Zain J, Chen CW, Rosen ST, Querfeld C. Identification of a Distinct miRNA Regulatory Network in the Tumor Microenvironment of Transformed Mycosis Fungoides. Cancers (Basel). 2021 Nov 22;13(22):5854.
- Han Z, Estephan RJ, Wu X, Su C, Yuan YC, Qin H, Kil SH, Morales C, Schmolze D, Sanchez JF, Tian L, Yu J, Kortylewski M, Rosen ST, Querfeld C. MicroRNA Regulation of T-Cell Exhaustion in Cutaneous T Cell Lymphoma. J Invest Dermatol. 2021 Nov 11:S0022-202X(21)02479-9.
- Zhang L, Nguyen LXT, Chen YC, Wu D, Cook GJ, Hoang DH, Brewer CJ, He X, Dong H, Li S, Li M, Zhao D, Qi J, Hua WK, Cai Q, Carnahan E, Chen W, Wu X, Swiderski P, Rockne RC, Kortylewski M, Li L, Zhang B, Marcucci G, Kuo YH. Targeting miR-126 in inv(16) acute myeloid leukemia inhibits leukemia development and leukemia stem cell maintenance. Nat Commun. 2021 Oct 22;12(1):6154.
- Zhang XH, Chen CH, Li H, Hsiang J, Wu X, Hu W, Horne D, Nam S, Shively J, Rosen ST: Targeting the non-ATP- binding pocket of the MAP kinase p38gamma mediates a novel mechanism of cytotoxicity in cutaneous T-cell lymphoma (CTCL). FEBS Lett 2021.
- Yuan W, Al-Hadid Q, Wang Z, Shen L, Cho H, Wu X, Yang Y: TDRD3 promotes DHX9 chromatin recruitment and R- loop resolution. Nucleic Acids Res 2021.
- Wang X, Huynh C, Urak R, Weng L, Walter M, Lim L, Vyas V, Chang WC, Aguilar B, Brito A et al: The Cerebroventricular Environment Modifies CAR T Cells for Potent Activity against Both Central Nervous System and Systemic Lymphoma. Cancer Immunol Res 2021, 9(1):75-88.
- Song Q, Wang X, Wu X, Qin H, Li Y, Riggs AD, Martin PJ, Chen YZ, Zeng D: Tolerogenic anti-IL-2 mAb prevents graft-versus-host disease while preserving strong graft-versus-leukemia activity. Blood 2021, 137(16):2243-2255.
- Song Q, Wang X, Wu X, Kang TH, Qin H, Zhao D, Jenq RR, van den Brink MRM, Riggs AD, Martin PJ et al: IL-22- dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice. Nat Commun 2021, 12(1):805.
- Song JY, Perry AM, Herrera AF, Chen L, Skrabek P, Nasr MR, Ottesen RA, Nikowitz J, Bedell V, Murata-Collins J et al: Double-hit Signature with TP53 Abnormalities Predicts Poor Survival in Patients with Germinal Center Type Diffuse Large B-cell Lymphoma Treated with R-CHOP. Clin Cancer Res 2021, 27(6):1671-1680.
- Salisbury DA, Casero D, Zhang Z, Wang D, Kim J, Wu X, Vergnes L, Mirza AH, Leon-Mimila P, Williams KJ et al: Transcriptional regulation of N(6)-methyladenosine orchestrates sex-dimorphic metabolic traits. Nat Metab 2021, 3(7):940-953.
- Saeki K, Chang G, Kanaya N, Wu X, Wang J, Bernal L, Ha D, Neuhausen SL, Chen S: Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis. Commun Biol 2021, 4(1):660.
- Saeki K, Chang G, Kanaya N, Wu X, Wang J, Bernal L, Ha D, Neuhausen SL, Chen S: Author Correction: Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis. Commun Biol 2021, 4(1):892.
- Reddy MA, Amaram V, Das S, Tanwar VS, Ganguly R, Wang M, Lanting L, Zhang L, Abdollahi M, Chen Z et al: lncRNA DRAIR is downregulated in diabetic monocytes and modulates the inflammatory phenotype via epigenetic mechanisms. JCI Insight 2021, 6(11).
- Olson AW, Le V, Wang J, Hiroto A, Kim WK, Lee DH, Aldahl J, Wu X, Kim M, Cunha GR et al: Stromal androgen and hedgehog signaling regulates stem cell niches in pubertal prostate development. Development 2021.
- Lee DH, Olson AW, Wang J, Kim WK, Mi J, Zeng H, Le V, Aldahl J, Hiroto A, Wu X et al: Androgen action in cell fate and communication during prostate development at single-cell resolution. Development 2021, 148(1).
- Kong X, Zeng D, Wu X, Wang B, Yang S, Song Q, Zhu Y, Salas M, Qin H, Nasri U et al: Tissue-resident PSGL1loCD4+ T cells promote B cell differentiation and chronic graft-versus-host disease-associated autoimmunity. J Clin Invest 2021, 131(1).